Natural Products in Renal-Associated Drug Discovery

The global increase in the incidence of kidney failure constitutes a major public health problem. Kidney disease is classified into acute and chronic: injury (AKI) associated with an abrupt decline function chronic (CKD) renal for more than three months. Although both syndromes are multifactorial, inflammation oxidative stress play roles diversity processes leading to these malfunctions. Here, we reviewed various publications on medicinal plants antioxidant anti-inflammatory properties potential treat manage kidney-associated diseases rodent models. Additionally, conducted meta-analysis identify gene signatures biological perturbed human mouse cells treated antioxidants such as epigallocatechin gallate (EGCG), active ingredient green tea, mushroom Ganoderma lucidum (GL) We identified EGCG- GL-regulated linked metabolism; (NRG1, E2F1, NFKB1 JUN); ion signalling; transport; (SLC12A1 LOX) VEGF, ERBB BDNF signalling. Medicinal plant extracts proving be effective prevention, management treatment diseases; however, detailed characterisations their targets needed enable trust application diseases.